provided its vital function in immunity, It's not at all stunning that extra MIF expression continues to be associated with exaggerated inflammation and immunopathology. Furthermore, MIF demonstrates properly-documented proliferative properties. MIF is secreted by several differing types of cells and interacts with several receptors, which assists to elucidate The variability of biological features. Receptors that interact that bind MIF include things like CD74, and chemokine receptors CXCR2 and CXCR4 (seven–15).
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MIF can travel its oncogenic signaling via both equally autocrine and paracrine manners. MIF is thought click here to bind With all the CD74 receptor to activate a number of inflammatory and survival pathways like MAPK and PI3K/Akt7, but the precise molecular mechanism will not be absolutely comprehended. Apparently, CD74 or MIF blockade lowered the aggressiveness of invasive breast cancer cells8.
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learned from the late nineteen sixties as a product of activated T cells, the cytokine macrophage migration inhibitory factor (MIF) continues to be discovered a short while ago to perform vital functions being a mediator from the innate immune program.
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